Agenda

Thursday, September 8, 2022

7:00 – 8:00 amRegistration & Refreshments
LOBBY & BALLROOM A, FIRST FLOOR
MAIN MEETING SESSION: BALLROOM B, SECOND FLOOR
8:10 – 8:10 amWelcome and Opening Remarks
Alison Morris, MD, MS; University of Pittsburgh
Janet Lee, MD; University of Pittsburgh
Tomeka Suber, MD, PhD; University of Pittsburgh
Session 1: THE STATE OF METABOLISM RESEARCH IN HEALTH SCIENCES: METABOLISM, BIOENERGETICS, AND THE TOOLS OF THE TRADE
Session Chairs:Janet S. Lee, MD; University of Pittsburgh
Anuradha Ray, PhD; University of Pittsburgh
Nathaniel Weathington, MD, PhD; UPMC
8:10 – 8:20 amSession Chair Introduction
8:20 – 8:40 amAging, Metabolism and Autophagy
Toren Finkel, MD, PhD
University of Pittsburgh
8:40 - 8:45 amQ & A
8:45 – 9:05 amOverview of Metabolomics Analysis
Stacy Gelhaus Wendell, PhD
University of Pittsburgh
9:05 - 9:10 amQ & A
9:10 – 9:30 amCellular Measurements and Metabolism
William M. Oldham, MD, PhD
Harvard Medical School
9:30 – 9:35 amQ & A
9:35 - 9:55 amRefreshment Break
BALLROOM A, FIRST FLOOR
MAIN MEETING SESSION: BALLROOM B, SECOND FLOOR
Session 2: ALTERATIONS TO METABOLISM AS A DRIVER OF PULMONARY VASCULAR DISEASE
Session Chairs: Mark Gladwin, MD; University of Pittsburgh
Brett Kaufman, PhD; University of Pittsburgh
9:55 - 10:00 am Session Chair Introduction
10:00 – 10:20 amAlterations to Metabolism as a driver of Pulmonary Vascular Disease
Sruti Shiva, PhD
University of Pittsburgh
10:20 - 10:25 amQ & A
10:25 – 10:45 am Noncoding RNAs Direct Metabolism in Pulmonary Hypertension Physiology
Stephen Y. Chan, MD, PhD, FAHA
University of Pittsburgh
10:45 - 10:50 amQ & A
10:50 - 11:05 amRefreshment Break
BALLROOM A, FIRST FLOOR
MAIN MEETING SESSION: BALLROOM B, SECOND FLOOR
Rapid Fire #1: EARLY CAREER ORAL PRESENTATIONS
Moderators: Fernando Holguin, MD; University of Colorado, Denver
Tomeka Suber, MD, PhD; University of Pittsburgh
11:05 – 11:10 amIntroductions
11:10 – 11:20 amAbstract Oral Presentation #1:
Lung Cell Profiling in Multiomic Mesenchymal Cell Profiling in Systemic
Sclerosis-associated Interstitial Lung Disease

Eleanor B. Valenzi, MD
University of Pittsburgh
11:20 – 11:25 amQ & A
11:25 – 11:35 amAbstract Oral Presentation #2:
Pulmonary Vascular Disease in COPD
Aparna Balasubramanian, MD, MHS
Johns Hopkins University School of Medicine
11:35 – 11:40 amQ & A
11:40 – 11:50 amAbstract Oral Presentation #3:
Airway Immune Pathways in Allergic Asthma
Jehan W. Alladina, MD
Massachusetts General Hospital, Harvard Medical School
11:50 – 11:55 amQ & A
12:00 – 12:45 pmLunch (provided)
GOLD ROOM, SECOND FLOOR
12:45 – 2:00 pmPoster Session and Refreshments
BALLROOM A, FIRST FLOOR
MAIN MEETING SESSION: BALLROOM B, SECOND FLOOR
Session 3: STUDYING AIRWAYS DISEASE THROUGH THE LENS OF METABOLISM
Session Chairs:Oliver Eickelberg, MD; University of Pittsburgh
Frank C. Sciurba, MD, FCCP; University of Pittsburgh
2:00 – 2:10 pmSession Chair Introduction
2:10 – 2:30 pmImmunometabolism Changes in COPD Patients
Suzanne Cloonan, PhD
Trinity College, Dublin
2:30 - 2:35 pmQ & A
2:35 - 2:55 pmThe Interplay of Metabolism and Regenerative Signaling Pathways in Chronic Lung Disease
Melanie Königshoff, MD, PhD
University of Pittsburgh
2:55 - 3:00 pmQ & A
3:00 - 3:20 pmAirway Neutrophil Metabolism Impacts Cystic Fibrosis Bacterial Colonization
Prof. Gerry McElvany
Royal College of Surgeons in Ireland
3:20 - 3:25 pmQ & A
3:25 - 3:45 pmRefreshment Break
BALLROOM A, FIRST FLOOR
MAIN MEETING SESSION: BALLROOM B, SECOND FLOOR
Session 4: UNLOCKING THE ROLE OF METABOLISM AND MITOCHONDRIA
IN LUNG PARENCHYMAL DISEASE AND CANCER
Session Chairs:Mauricio Rojas, MD; Ohio State University
Nadia Hansel, MD; Johns Hopkins School of Medicine
3:45 – 3:50 pmSession Chair Introduction
3:50 – 4:10 pmMitochondrial Changes in Idiopathic Pulmonary Fibrosis
Ana Mora, MD
Ohio State University
4:10 – 4:15 pmQ & A
4:15 – 4:35 pmDiverse Metabolic Signaling in Myeloid Cells as a Driver of Fibrotic Lung Disease
G.R. Scott Budinger, MD
Northwestern Feinberg School of Medicine
4:35 – 4:40 pmQ & A
4:40 – 5:00 pmCrosstalk Between Tumor and Immune Metabolism in the Cancer Microenvironment
Greg M. Delgoffe, PhD
University of Pittsburgh
5:00 – 5:05 pmQ & A
5:05 – 5:25 pmMitochondria of Alveolar Type 2 Cells Determine Severity of the Lung’s Innate Immunity
M. Naeem Islam, PhD
Vagelos Columbia College of P&S
5:25 – 5:30 pmQ & A
5:45 pmAdjournment
5:45 – 6:15 pmTravel Time to Reception
6:00 – 9:00 pmReception
CARNEGIE SCIENCE CENTER
(please wear your name badge for admittance)

"Do you believe in miracles? Yes, at the Monongahela River!"
Special guest speaker:
Augustine M.K. Choi, MD;

Stephen and Suzanne Weiss Dean, Weill Cornell Medicine
Provost for Medical Affairs, Cornell University
9:00 pmReturn Transportation to Hotels

Friday, September 9, 2022

7:30 – 8:00 amRegistration and Refreshments
LOBBY & BALLROOM A, FIRST FLOOR
MAIN MEETING SESSION: BALLROOM B, SECOND FLOOR
Session 5: METABOLISM AS A DRIVER OF IMMUNE RESPONSES AND
IN PULMONARY TRANSPLANT

Session Chairs:Chadi Hage, MD; University of Pittsburgh
Mark Snyder, MD; University of Pittsburgh
8:00 – 8:15 amWelcome and Session Chair Introduction
8:15 – 8:35 amMitochondrial ROS Fine-tunes Lung Dendritic Cells to Regulate Allergic Disease
Anuradha Ray, PhD
University of Pittsburgh
8:35 – 8:40 amQ & A
8:40 – 9:00 amImmunometabolism as a Determinant in Success or Failure of Bone Marrow Transplant
Craig A. Byersdorfer, MD, PhD
University of Pittsburgh
9:00 – 9:05 amQ & A
9:05 – 9:20 amRefreshment Break
BALLROOM A, FIRST FLOOR
MAIN MEETING SESSION: BALLROOM B, SECOND FLOOR
Session 6: MODULATIONS OF METABOLISM IN IMMUNITY AND INFECTION
Session Chairs: Barbara Methé, PhD; University of Pittsburgh
Prabir Ray, PhD; University of Pittsburgh
9:20 – 9:25 amSession Chair Introduction
9:25 – 9:45 amPersistence of Klebsiella and Pseudomonas in the Respiratory Tract by Metabolite Adaptation and Implications in Pathogenicity
Alice Prince, MD
Columbia University
9:45 – 9:50 amQ & A
9:50 – 10:10 amMetabolic Determinants in the Pathogenesis of Legionella Infection
Sunny Shin, PhD
University of Pennsylvania
10:10 – 10:15 amQ & A
10:15 – 10:35 amPseudomonas Microbial Metabolism and Adaptation in the CF Microenvironment
Jennifer M. Bomberger, PhD
Geisel School of Medicine at Dartmouth
10:35 – 10:40 amQ & A
10:40 – 11:00 AMRefreshment Break
BALLROOM A, FIRST FLOOR
MAIN MEETING SESSION: BALLROOM B, SECOND FLOOR
Rapid Fire #2EARLY CAREER ORAL PRESENTATIONS
Moderator: Jessica Bon, MD, MS; University of Pittsburgh
Anna Zemke, MD, PhD; University of Pittsburgh
11:00 – 11:05 amIntroductions
11:05 – 11:15 amAbstract Oral Presentation #4:
Immune Pathways in Severe Asthma
Marc C. Gauthier, MD
University of Pittsburgh
11:15 – 11:20 amQ & A
11:20 – 11:30 amAbstract Oral Presentation #5:
Metabolism in the Lung Microbiome after Lung Transplantation
John E. McGinniss, MD
University of Pennsylvania
11:30 – 11:35 amQ & A
11:35 – 11:45 amAbstract Oral Presentation #6:
Maresin 1/LGR6 axis in the resolution of Respiratory Syncytial Virus- induced inflammation
Nandini Krishnamoorthy, PhD
Harvard Medical School, Brigham & Women’s Hospital
11:45 – 11:50 amQ & A
11:50 am – 1:00 pmLunch (provided)
GOLD ROOM, SECOND FLOOR
MAIN MEETING SESSION: BALLROOM B, SECOND FLOOR
1:00 – 2:00 pmPanel Discussion
CHANGING PATTERNS OF PUBLICATIONS AND ITS IMPACT ON ACADEMIC SUCCESS
  • Rama Mallampalli, MD; Associate Editor, American Journal of Respiratory Cell & Molecular Biology
  • Lorraine Ware, MD; Past President, The American Society for Clinical Investigation
  • Corinne Williams, PhD; Senior Science Editor, The Journal of Clinical Investigation and JCI Insight
2:00 – 2:15 pmRefreshment Break
BALLROOM A, FIRST FLOOR
MAIN MEETING SESSION: BALLROOM B, SECOND FLOOR
Session 7:METABOLIC AND PHYSIOLOGIC DETERMINANTS OF COVID PATHOGENESIS
Session Chairs:Georgios Kitsios, MD, PhD; University of Pittsburgh
John McDyer, MD; University of Pittsburgh
2:15 – 2:20 pmSession Chair Introduction
2:20 – 2:40 pmImmuno-metabolomes and Immuno-lipidomes in COVID-19
Charles Dela Cruz, MD, PhD
Yale University
2:40 – 2:45 pmQ & A
2:45 – 3:05 pmMetabolic Vulnerabilities in COVID-19
Peter Mullen, PhD
USC Keck School of Medicine
3:05 – 3:10 pmQ & A
3:10 – 3:35 pmRefreshment Break
BALLROOM A, FIRST FLOOR
MAIN MEETING SESSION: BALLROOM B, SECOND FLOOR
Session 8:TARGETING METABOLISM FOR NOVEL THERAPIES
Session Chairs:Faraaz Shah, MD, MPH; University of Pittsburgh
Bruce Levy, MD; Harvard University School of Medicine
3:35 – 3:40 pmSession Chair Introduction
3:40 – 4:00 pmUnderstanding Metabolic Changes in Patients with Sepsis
Matthew Rosengart, MD, MPH
University of Pittsburgh

4:00 – 4:05 pmQ & A
4:05 – 4:25 pmThe Interplay of Metabolism and Sleep Physiology
Vsevolod Y. Polotsky, MD, PhD
Johns Hopkins University
4:25 – 4:30 pmQ & A
4:30 – 4:45 pmPoster Recognitions
4:45 – 5:00 pmConcluding Remarks
Alison Morris, MD, MS
5:00 pmAdjournment